Molybdenum (Mo)
Recognized as a new element in 1778, the first impure form of molybdenum was produced in 1782.
The metal is silvery white and very hard, although softer and more ductile than tungsten. Used as an alloying agent, it makes quenched and tempered steels both harder and tougher and improves their strength at high temperatures. Molybdenum oxidizes at elevated temperatures.
It is used in nickel-based alloys that are heat and corrosion-resistant. The metal has been used for electrically heated glass furnace and fore hearth electrodes, in nuclear energy applications, and in aircraft and missile parts.
Molybdenum is an essential trace element for nitrogen fixation and other metabolic processes.
Apexbio Technology LLC TH-302 918633-87-1 10mM (in 1mL DMSO)
TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity
Apexbio Technology LLC UROLITHIN-M5-5MG
Urolithin M5 (CAS No 91485-02-8) is a bioactive metabolite of ellagic acid researched primarily in the fields of cancer and aging due to its potential therapeutic benefits It originates from the human gut microbiota following the ingestion of ellagitannins found in foods like pomegranates and berries The compound is known to modulate key cellular pathways including antioxidant and anti-inflammatory processes and has been studied for its ability to inhibit cell proliferation by targeting molecular pathways involved in cancer cell growth In vitro Urolithin M5 exhibits activity in the nanomolar to low micromolar range demonstrating significant potential in various experimental models It is commonly used in cell-based assays and animal studies to explore its effects on cellular health and longevity as well as its role as a candidate for drug screening in oncology research Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC UROLITHIN-M5-1MG
Urolithin M5 (CAS No 91485-02-8) is a bioactive metabolite of ellagic acid researched primarily in the fields of cancer and aging due to its potential therapeutic benefits It originates from the human gut microbiota following the ingestion of ellagitannins found in foods like pomegranates and berries The compound is known to modulate key cellular pathways including antioxidant and anti-inflammatory processes and has been studied for its ability to inhibit cell proliferation by targeting molecular pathways involved in cancer cell growth In vitro Urolithin M5 exhibits activity in the nanomolar to low micromolar range demonstrating significant potential in various experimental models It is commonly used in cell-based assays and animal studies to explore its effects on cellular health and longevity as well as its role as a candidate for drug screening in oncology research Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC UROLITHIN-M5-50MG
Urolithin M5 (CAS No 91485-02-8) is a bioactive metabolite of ellagic acid researched primarily in the fields of cancer and aging due to its potential therapeutic benefits It originates from the human gut microbiota following the ingestion of ellagitannins found in foods like pomegranates and berries The compound is known to modulate key cellular pathways including antioxidant and anti-inflammatory processes and has been studied for its ability to inhibit cell proliferation by targeting molecular pathways involved in cancer cell growth In vitro Urolithin M5 exhibits activity in the nanomolar to low micromolar range demonstrating significant potential in various experimental models It is commonly used in cell-based assays and animal studies to explore its effects on cellular health and longevity as well as its role as a candidate for drug screening in oncology research Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC UROLITHIN-M5-25MG
Urolithin M5 (CAS No 91485-02-8) is a bioactive metabolite of ellagic acid researched primarily in the fields of cancer and aging due to its potential therapeutic benefits It originates from the human gut microbiota following the ingestion of ellagitannins found in foods like pomegranates and berries The compound is known to modulate key cellular pathways including antioxidant and anti-inflammatory processes and has been studied for its ability to inhibit cell proliferation by targeting molecular pathways involved in cancer cell growth In vitro Urolithin M5 exhibits activity in the nanomolar to low micromolar range demonstrating significant potential in various experimental models It is commonly used in cell-based assays and animal studies to explore its effects on cellular health and longevity as well as its role as a candidate for drug screening in oncology research Experimental concentrations typically depend on the specific research design
Medchemexpress LLC Phospho-MAPKAPK2 (Thr334) Antibody | 50 UL
This liquid, non-conjugated antibody is suitable for WB, IHC-P, and ICC/IF applications. It is formulated in PBS containing 150 mM NaCl, 50% glycerol, and 0.02% sodium azide at pH 7.4.
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Recommended dilution ratios: WB: 1:500-1:1000; IHC-P: 1:50-1:100; ICC/IF: 1:100-1:200
- Storage and stability: Stored at -20°C for 1 year, avoiding repeated freeze/thaw cycles
- Shipping: Shipped with blue ice
- SwissProt ID: P49137
- Gene ID: 9261
![Alkali Scientific TES, Free Acid [2 Tris(hydroxymethyl) methyl 2 amino 1 ethanesulfonic acid], 1 Kilogram](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660485.jpg-250.jpg)
Alkali Scientific TES, Free Acid [2 Tris(hydroxymethyl) methyl 2 amino 1 ethanesulfonic acid], 1 Kilogram
TES (Free Acid), also known as Tris(hydroxymethyl) methyl 2 amino 1 ethanesulfonic acid in its free acid form, is a widely used biochemical reagent for laboratory applications. This 1-kilogram package provides a highly stable buffer for experiments requiring an acidic environment. It is particularly useful in maintaining pH stability in enzymatic reactions and protein studies. TES is often used in place of Tris or phosphate buffers, providing a lower pH range that is essential for specific biochemical reactions, including electrophoresis and enzyme activity assays. This reagent is highly effective in both academic and industrial laboratories for various biochemical and molecular biology research applications.
Medchemexpress LLC TES-991 | 1883602-20-7 | 99.7% | 393.45 | 50 MG
TES-991 is a potent and selective human α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC50 of 3 nM. It is for research use only. This compound significantly increases intracellular NAD+ levels, and in vivo studies show low blood clearance and moderate systemic exposure after oral administration.
- Potent and selective ACMSD inhibitor (IC50 of 3 nM).
- Significantly increases intracellular NAD+ levels.
- Low blood clearance and volumes of distribution (in vivo studies).
- Moderate systemic exposure after oral administration (in vivo studies).
- Stable for 3 years at -20°C as powder.
- Stable for 2 years at -80°C in solvent.
Medchemexpress LLC Urolithin M5 | 91485-02-8 | 5 MG
Urolithin M5 is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent. It inhibits viral replication, including oseltamivir-resistant strains, and offers protection in infected mammals by reducing lung edema. It also provides neuroprotection by reducing reactive oxygen species, inhibiting neuronal apoptosis, and promoting neurite outgrowth.
- Orally active influenza virus neuraminidase inhibitor
- Neuroprotective agent
- Suppresses viral neuraminidase activity
- Inhibits influenza virus replication
- Protects infected mammals and improves lung edema
- Reduces reactive oxygen species production
- Inhibits neuronal apoptosis
- Restores mitochondrial transmembrane potential
- Promotes neurite outgrowth in damaged neuronal cells
- Suitable for research related to influenza and Alzheimer's disease